Artículos

Manual de interpretación 22C3.
Carcinoma de células escamosas de cabeza y cuello

Carcinoma de células escamosas de cabeza y cuello

PD-L1 IHC 22C3 pharmDx is the only companion diagnostic FDA-approved as an aid in identifying patients with head and neck squamous cell carcinoma (HNSCC) for treatment with KEYTRUDA® (pembrolizumab). This Interpretation Manual is provided as a tool to help guide pathologists and laboratory personnel in achieving correct and reproducible results in assessing PD-L1 expression in FFPE HNSCC specimens.

Implementation of the 2018 guidelines on HER2 Assessment in breast cancer

Implementation of the 2018 guidelines on HER2

Human epidermal growth factor receptor 2 protein (HER2/ neu or  HER2), encoded by the ERBB2 gene located on the long arm of chromosome 17, is a transmembrane tyrosine kinase protein. HER2 amplification and/or overexpression occurs in up to 20% of invasive breast cancers is linked with aggressive disease and poor prognosis…

 Pathological findings of COVID19 associated with acute respiratory distress syndrome

Pathological findings of COVID19

Since late December, 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was reported in Wuhan, China, which has subsequently affected 26 countries worldwide. In general, COVID-19 is an acute resolved disease but it can also be deadly, with a 2% case fatality rate.

Diffuse alveolar damage (DAD) resulting from coronavirus disease 2019 Infection is Morphologically Indistinguishable from Other Causes of DAD

Diffuse alveolar damage

An aim of this study was to assess lung autopsy findings in COVID-19 inpatients, and in untreated severe acute respiratory syndrome coron- avirus 2 (SARS-CoV-2)-positive individuals who died in the community…

Mutational concordance between primary and metastatic melanoma

Mutational concordance between primary and metastatic melanoma

An aim of this study was to assess lung autopsy findings in COVID-19 inpatients, and in untreated severe acute respiratory syndrome coron- avirus 2 (SARS-CoV-2)-positive individuals who died in the community…

core biopsy postmortem and COVID

Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia.

EURACAN IASLC proposals for updating the histologic classification of pleural mesothelioma towards a more multidisciplinary approach

EURACAN IASLC

PD-L1 IHC 22C3 pharmDx is the only companion diagnostic FDA-approved as an aid in identifying patients with head and neck squamous cell carcinoma (HNSCC) for treatment with KEYTRUDA® (pembrolizumab). This Interpretation Manual is provided as a tool to help guide pathologists and laboratory personnel in achieving correct and reproducible results in assessing PD-L1 expression in FFPE HNSCC specimens.

Natural history of ovarian high grade serous carcinoma

Natural history of ovarian high grade serous carcinoma

High grade serous carcinoma is the most common and devastating type of ovarian cancer; its etiology, mechanism of malignant transformation, and origin remain controversial. Recent studies have identified secretory cells at the fimbria of the fallopian tube  as the cell-of-origin of high-grade serous carcinoma, acquiring TP53 mutation…